This work is a comprehensive monograph of Cremanthodium Benth. (Asteraceae, Senecioneae), a typical high-alpine genus endemic to the Sino-Himalayan region. Two species and one variety are described as new, seven names are treated as synonyms, one new combination is proposed, the independent specific status of four species is reinstated, lectotypes of 39 names are designated, and infrageneric placement of 14 species at sectional or series levels are adjusted. In addition, the geographical distribution of most species and varieties is clarified. In total, 80 species and nine varieties are recognized in the genus. The taxonomic treatment of each entry comprises a full synonymy with bibliographic citations, details of nomenclatural types or necessary new typifications, a full description, information on phenology, habitats, altitudinal ranges, geographical distribution, etymology, chromosome number, conservation status, detailed taxonomic notes, a full citation of herbarium specimens examined, and a distribution map. Type specimens and color photographs of herbarium specimens and living plants are, when available, also given for most species and varieties. Historically, plants of Cremanthodium received relatively little attention. Although incomparable in reputation with those most well-known high-alpine genera, such as Gentiana, Meconopsis, Primula, and Rhododendron, Cremanthodium gains, however, more and more attention from botanists and alpine plant enthusiasts due to the loveliness and magnificence of plants of the genus, especially from those who are in deep love with plants in the Himalayan region. The publication of this book represents another important contribution by Chinese botanists to the field of plant taxonomy. The book should be of important value of reference for experts and scholars at research institutes, teachers and students from related fields in colleges, professionals, and amateurs in botany and horticulture, and those engaged in plant resource utilization and nature conservation.